Grant CPP2023-01050 funded by MCIN/AEI/10.13039/501100011033 and by FEDER,UE
In APOLO project, ur goal is to develop a mapping system that combines structural and functional heart information, along with the creation of personalized digital cardiac twins, to support the prevention and treatment of cardiac arrhythmias. This new system must:
- Be the first system capable of integrating structural (e.g., fibrosis) and functional (e.g., electrical properties) information in both ventricles volumetrically (i.e., endo-epicardially).
- Estimate a patient’s probability of experiencing an arrhythmia and simulate the most appropriate treatment to guide the clinician to the cardiac region causing the arrhythmia.
- Help improve patients’ quality of life, increase the effectiveness of ICD and cardiac ablation treatments, and reduce associated healthcare costs.
Methodology
The APOLO consortium will combine Corify Care’s functional electrophysiological mapping technology (electrocardiographic imaging, ECGI) with ADAS3D’s structural cardiac mapping technology and UPV’s artificial intelligence and mathematical modeling tools to develop an innovative device that enhances the entire cardiac patient treatment workflow. This technology will be validated through preclinical studies in porcine models to assess mapping accuracy, followed by multicenter prospective clinical studies coordinated by IDIBAPS to demonstrate its effectiveness in improving ventricular tachycardia ablation and identifying patients who require an implantable cardioverter-defibrillator (ICD).
Impact
The APOLO technological solution will increase the effectiveness of treatments for sudden cardiac death prevention, improving the number of patients who respond to therapy and reducing healthcare costs. Additionally, it will accelerate the development of a new generation of medical devices aimed at advancing precision medicine. Finally, the project will foster the business growth of Corify Care and ADAS3D. Based on market trends in electrophysiology devices and the epidemiology of targeted arrhythm
