PhD, Group Leader, ICREA Research Professor
President of EVBO, Endothelial Pathobiology and Microenvironment Group, Josep Carreras Leukaemia Research Institute, Barcelona, Catalonia, SPAIN
Behaviours of cancer-associated mutations in vascular malformations
Host: S. Zacchigna
Abstract
Vascular malformations (VMs) represent a broad spectrum of lesions related to disorders in vascular development, which can give rise to a wide range of clinical features depending on the extent of the lesion and the affected tissue. These lesions are often congenital and grow over the time, mainly affecting infants, children, and young adults. VMs are classified in high- flow (arteriovenous) and low-flow (venous, capillary and lymphatic) malformations. Specifically, a large proportion of low-flow lesions are caused by somatic mutations in cancer-related genes, leading to the overactivation of the signalling pathway commonly affected in tumours. In may talk, I will discuss which a variety of pathogenic outcomes imposed by these mutations, and which are the molecular mechanisms underlying their expression.
International Seminar Programme
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