ERASMUS MC, Rotterdam, The Netherlands
Mechanisms of HIV-1 latency and how to measure the persistence reservoir
Host: N. Chigorimbo-Tsikiwa
Abstract
Tokameh Mahmoudi studied Molecular Biology at UC Berkeley where she completed her Bachelor’s degree followed by her Masters studies in Biochemistry at the Hospital for Sick Children, University of Toronto. She performed her PhD research at Leiden University Medical Centre (LUMC) in Leiden, The Netherlands where she studied the role of trithorax and polycomb group proteins in chromatin mediated gene regulation. As a trained biochemist she applied her expertise into mechanistic dissection of the molecular events that drive viral pathogenesis and latency during her post-doctoral studies at UCSF at the Gladstone Institute of Immunology and Virology in the lab of Eric Verdin and later in stem cell based technologies in the lab of Hans Clevers at the Hubrecht Institute in The Netherlands. Research in Tokameh’s lab focuses on delineation of the molecular events that control HIV transcriptional latency and HBV- mediated onset of hepatocellular carcinoma (HCC). Her lab uses a multidisciplinary approach combining current knowledge of HIV transcription and HBV infection together with state of the art high through-put approaches, virology, genetics, immunology and conventional biochemistry to identify novel druggable molecular targets and candidate therapeutics. Tokameh is a member of NL-4Cure and co-founder of EHEG, an Erasmus MC multidisciplinary consortium focused on translating basic advances in HIV Cure research into development of novel therapeutics and their testing and implementation in the clinic.
International Seminar Programme
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