Molecular Biology , University of Padova, ITALY
From Forces to Forms: the blueprints of malignancy and how to dismantle them
Host: G. Del Sal
Abstract
How do cells build tissues, and how does cancer hijack this ability?
I will discuss how mechanical forces govern cell identity and collective behavior, and what they reveal
about the logic of tissue organization.
Our three-dimensional studies show how breast cancers repurpose developmental programs to build
architectures that sustain metastatic growth. Spatial and computational pathology extend this view
to cellular ecosystems, linking their organization on routine histology to patient outcome.
Knowing how malignant tissues are built sharpens a therapeutic question: which signals and cellular
partnerships must we disrupt to halt their construction?
International Seminar Programme
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