Metastatic Castration-Resistant Prostate Cancer (mCRPC) refers to prostate cancer that has spread (metastasized) to other parts of the body and continues to progress despite treatments that lower testosterone levels (androgen deprivation therapy or ADT) major pharmaceutical companies are heavily investing in research and development of new treatments, including immunotherapy (e.g., sipuleucel-T) and targeted therapies, which are seen as the next frontier in treating mCRPC. The use of precision medicine to identify genetic profiles in patients has further expanded the potential for targeted treatment.
LAS VEGAS , Oct. 10, 2024 /PRNewswire/ -- DelveInsight's 'Metastatic Castration-Resistant Prostate Cancer Pipeline Insight 2024 [https://www.delveinsight.com/report-store/metastatic-castration-resistant-prostate-cancer-pipeline-insight?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]' report provides comprehensive global coverage of pipeline mCRPC therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the mCRPC pipeline domain.
https://mma.prnewswire.com/media/1082265/3528414/DelveInsight_Logo.jpg [https://mma.prnewswire.com/media/1082265/3528414/DelveInsight_Logo.jpg]
Key Takeaways from the Metastatic Castration-Resistant Prostate Cancer Pipeline Report
-- DelveInsight's mCRPC pipeline report depicts a robust space with 90+
active players working to develop 100+ pipeline therapies for mCRPC
treatment.
-- Key mCRPC companies such as Regeneron Pharmaceuticals, AstraZeneca,
Hinova Pharmaceuticals, Zenith Epigenetic, Eli Lilly and Company,
Astellas Pharma, Seagen, Pfizer, Progenics Pharmaceutical, Molecular
Insight Pharmaceuticals, Bayer, Accutar Biotechnology Inc, Hinova
Pharmaceuticals, Forma Therapeutics, Inc., HALDA THERAPEUTICS INC.,
Tavanta Therapeutics, Lantheus, Pfizer, AB Science, Syntrix
Pharmaceuticals, Exelixis, Laekna Therapeutics Shanghai Co. Ltd.,
Cardiff Oncology, Ipsen, Norroy Bioscience, Astellas Pharma, Novartis,
Johnson & Johnson, Tempest Therapeutics, and others are evaluating new
mCRPC drugs to improve the treatment landscape.
-- Promising mCRPC pipeline therapies such as REGN 4336, Capivasertib,
Deutenzalutamide, ZEN003694, Abemaciclib, Enfortumab vedotin,
Talazoparib, I-131-1095, Pelgifatamab corixetan, AC176, HP518, FT-7051,
HLD-0915, TAVT-45, PNT2002, Mevrometostat, Masitinib, SX-682, XL092,
LAE001, Onvansertib, Tazemetostat, 177Lu-NYM032, PRL-02, 225 Actinium
PSMA 617, ARX51, TPST-1120, and others are under different phases of
mCRPC clinical trials.
-- In October 2024, Curium announced that it had entered into a strategic
partnership with PDRadiopharma Inc, a wholly-owned subsidiary of
PeptiDream, for the clinical development, regulatory filing, and
commercialization in Japan of 177Lu-PSMA-I&T and 64Cu-PSMA-I&T. The two
agents 177Lu-PSMA-I&T and 64Cu-PSMA-I&T target prostate-specific
membrane antigen (PSMA) expressed on prostate cancer cells and are being
investigated for prostate cancer treatment and diagnostics.
-- In July 2024, the US FDA granted fast-track designation to the
prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical
225Ac-FL-020 for the treatment of patients with metastatic
castration-resistant prostate cancer (mCRPC).
-- In July 2024, Merck and Orion Corporation announced the mutual exercise
of option providing Merck global exclusive rights to Opevesostat, an
investigational CYP11A1 inhibitor, for the treatment of Metastatic
Castration-Resistant Prostate Cancer.
-- In July 2024, the US FDA granted fast-track designation to the
antibody-drug conjugate (ADC) BNT324/DB-1311 to potentially treat
patients with unresectable advanced or metastatic castration-resistant
prostate cancer (mCRPC) whose disease had progressed on or after
standard systemic regimens.
-- In July 2024, FutureChem announced that the FC-705 has received orphan
drug designation from the Ministry of Food and Drug Safety (MFDS) for
the treatment of prostate cancer.
-- In June 2024, CAR T-Cell Therapy demonstrated promising results for
mCRPC according to Phase I trial results.
-- In January 2024, Lava Therapeutics announced that it has signed a
clinical trial collaboration and supply agreement with Merck to evaluate
its prostate cancer therapy LAVA-1207 as a combination treatment with
MSD's Keytruda (pembrolizumab).
-- In July 2024, Blue Earth Therapeutics announced the signing of a
clinical research collaboration with University College London (UCL).
The collaboration is centered on a Phase I/II trial designed to evaluate
the safety, tolerability, radiation dosimetry, and antitumor activity of
the 225Ac-rhPSMA-10.1 in men with metastatic castrate-resistant prostate
cancer who have previously responded to lutetium 177 (177Lu)-PSMA
therapy.
Request a sample and discover the recent advances in mCRPC treatment drugs @ Metastatic Castration-Resistant Prostate Cancer Pipeline Report [https://www.delveinsight.com/sample-request/metastatic-castration-resistant-prostate-cancer-pipeline-insight?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]
The mCRPC pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage mCRPC drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the mCRPC clinical trial landscape.
Metastatic Castration-Resistant Prostate Cancer Overview
Metastatic castration-resistant prostate cancer (mCRPC) is an advanced stage of prostate cancer that continues to grow and spread despite hormone therapy aimed at lowering testosterone levels. The term "metastatic" refers to cancer spreading to other parts of the body, such as the bones, lymph nodes, or distant organs, while "castration-resistant" indicates that the cancer no longer responds to treatments that reduce testosterone, a key driver of prostate cancer growth. mCRPC is typically more aggressive and challenging to treat than earlier stages of prostate cancer.
The causes of mCRPC stem from genetic and environmental factors. Genetic mutations in the androgen receptor pathway can make cancer cells less dependent on testosterone, allowing them to thrive even under hormone-suppressing treatments. Environmental factors like diet, lifestyle, and exposure to certain chemicals may also contribute to the development and progression of prostate cancer. Symptoms of mCRPC often include pain in bones, fatigue, difficulty urinating, weight loss, and general weakness. As the cancer spreads, it can impair the function of other organs, depending on the site of metastasis.
Diagnosis of mCRPC usually involves a combination of tests, including prostate-specific antigen (PSA) blood tests, imaging studies like CT scans, MRIs, or bone scans, and sometimes biopsies to confirm the spread and resistance to treatment. Treatment options for mCRPC are more complex and may include newer hormonal therapies (e.g., abiraterone, enzalutamide), chemotherapy (docetaxel or cabazitaxel), immunotherapy (e.g., sipuleucel-T), or targeted therapies such as PARP inhibitors. Bone-targeting therapies, radiation, and palliative care can also be used to manage symptoms and improve the quality of life. Treatment is typically tailored to the individual based on the extent of the disease and the patient health.
Find out more about mCRPC treatment drugs @ Drugs for Metastatic Castration-Resistant Prostate Cancer Treatment [https://www.delveinsight.com/sample-request/metastatic-castration-resistant-prostate-cancer-pipeline-insight?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]
A snapshot of the mCRPC Pipeline Drugs mentioned in the report:
Drugs Company Phase MoA RoA Deutenzalutamide (HC-1119) Hinova Pharmaceuticals Registration Androgen receptor antagonists Oral Capivasertib AstraZeneca Phase III Proto-oncogene protein c-akt inhibitors Oral Abemaciclib Eli Lilly and Phase III Cyclin-dependent kinase 4 inhibitors; Company Cyclin-dependent kinase 6 inhibitors Oral ZEN003694 Zenith Epigenetic Phase II Bromodomain and extraterminal domain protein inhibitors Oral REGN 4336 Regeneron Phase I/ Antibody-dependent cell cytotoxicity Subcutaneous/ Pharmaceuticals II Intravenous HP518 Hinova Pharmaceuticals Phase I Androgen receptor degradation enhancers Oral 225 Actinium PSMA 617 Novartis Phase I Ionizing radiation emitters Intravenous TPST-1120 Tempest Therapeutics Phase I PPAR alpha antagonists Oral
Learn more about the emerging mCRPC pipeline therapies @ Metastatic Castration-Resistant Prostate Cancer Clinical Trials [https://www.delveinsight.com/sample-request/metastatic-castration-resistant-prostate-cancer-pipeline-insight?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]
Metastatic Castration-Resistant Prostate Cancer Therapeutics Assessment
The mCRPC pipeline report proffers an integral view of the mCRPC emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration.
Scope of the Metastatic Castration-Resistant Prostate Cancer Pipeline Report
-- Coverage: Global
-- Therapeutic Assessment By Product Type: Mono, Combination,
Mono/Combination
-- Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical,
Phase I, Phase II, Phase III
-- Therapeutics Assessment By Route of Administration: Oral, Intravenous,
Subcutaneous
-- Therapeutics Assessment By Molecule Type: Small molecule, Cell therapy,
Peptides, Polymer, Small molecule, Gene therapy
-- Therapeutics Assessment By Mechanism of Action: Androgen receptor
degradation enhancers, Antibody-dependent cell cytotoxicity,
Proto-oncogene protein c-akt inhibitors, Androgen receptor antagonists,
Bromodomain and extraterminal domain protein inhibitors,
Cyclin-dependent kinase 4 inhibitors, Cyclin-dependent kinase 6
inhibitors, Ionizing radiation emitters, PPAR alpha antagonists.
-- Key Metastatic Castration-Resistant Prostate Cancer Companies: Regeneron
Pharmaceuticals, AstraZeneca, Hinova Pharmaceuticals, Zenith Epigenetic,
Eli Lilly and Company, Astellas Pharma, Seagen, Pfizer, Progenics
Pharmaceutical, Molecular Insight Pharmaceuticals, Bayer, Accutar
Biotechnology Inc, Hinova Pharmaceuticals, Forma Therapeutics, Inc.,
HALDA THERAPEUTICS INC., Tavanta Therapeutics, Lantheus, Pfizer, AB
Science, Syntrix Pharmaceuticals, Exelixis, Laekna Therapeutics Shanghai
Co. Ltd., Cardiff Oncology, Ipsen, Norroy Bioscience, Astellas Pharma,
Novartis, Johnson & Johnson, Tempest Therapeutics, and others.
-- Key Metastatic Castration-Resistant Prostate Cancer Pipeline Therapies:
REGN 4336, Capivasertib, Deutenzalutamide, ZEN003694, Abemaciclib,
Enfortumab vedotin, Talazoparib, I-131-1095, Pelgifatamab corixetan,
AC176, HP518, FT-7051, HLD-0915, TAVT-45, PNT2002, Mevrometostat,
Masitinib, SX-682, XL092, LAE001, Onvansertib, Tazemetostat,
177Lu-NYM032, PRL-02, 225 Actinium PSMA 617, ARX51, TPST-1120, and
others.
Dive deep into rich insights for new drugs for mCRPC treatment, visit @ Metastatic Castration-Resistant Prostate Cancer Drugs [https://www.delveinsight.com/sample-request/metastatic-castration-resistant-prostate-cancer-pipeline-insight?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]
Table of Contents
1. Metastatic Castration-Resistant Prostate Cancer Pipeline Report Introduction 2. Metastatic Castration-Resistant Prostate Cancer Pipeline Report Executive Summary 3. Metastatic Castration-Resistant Prostate Cancer Pipeline: Overview 4. Analytical Perspective In-depth Commercial Assessment 5. Metastatic Castration-Resistant Prostate Cancer Clinical Trial Therapeutics 6. Metastatic Castration-Resistant Prostate Cancer Pipeline: Late-Stage Products (Pre-registration) 7. Metastatic Castration-Resistant Prostate Cancer Pipeline: Late-Stage Products (Phase III) 8. Metastatic Castration-Resistant Prostate Cancer Pipeline: Mid-Stage Products (Phase II) 9. Metastatic Castration-Resistant Prostate Cancer Pipeline: Early-Stage Products (Phase I) 10. Metastatic Castration-Resistant Prostate Cancer Pipeline Therapeutics Assessment 11. Inactive Products in the Metastatic Castration-Resistant Prostate Cancer Pipeline 12. Company-University Collaborations (Licensing/Partnering) Analysis 13. Key Companies 14. Key Products in the Metastatic Castration-Resistant Prostate Cancer Pipeline 15. Unmet Needs 16. Market Drivers and Barriers 17. Future Perspectives and Conclusion 18. Analyst Views 19. Appendix
For further information on the mCRPC Cancer pipeline therapeutics, reach out @ Metastatic Castration-Resistant Prostate Cancer Treatment Drugs [https://www.delveinsight.com/sample-request/metastatic-castration-resistant-prostate-cancer-pipeline-insight?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]
Related Reports
Metastatic Castration-Resistant Prostate Cancer Market [https://www.delveinsight.com/report-store/metastatic-castration-resistant-prostate-cancer-mcrpc-market?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]
Metastatic Castration-Resistant Prostate Cancer Market Insights, Epidemiology, and Market Forecast - 2034 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, market share of the individual therapies, and key mCRPC companies including AstraZeneca, Merck Sharp & Dohme, Hinova Pharmaceuticals, Pfizer, Astellas Pharma, Modra Pharmaceuticals, AB Science, Eli Lilly and Company, Zr Pharma & GmbH, Bristol-Myers Squibb, Ipsen, Exelixis, Takeda, Janssen Research & Development, Tesaro, Lantheus Holdings, Kintor Pharmaceutical, MacroGenics, Daiichi Sankyo, Madison Vaccines, Novartis, Point Biopharma, Xencor, Essa Pharma, Telix International, Bayer, Arvinas, among others.
Metastatic Prostate Cancer Market [https://www.delveinsight.com/report-store/metastatic-prostate-cancer-market?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]
Metastatic Prostate Cancer Market Insights, Epidemiology, and Market Forecast - 2034 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, market share of the individual therapies, and key metastatic prostate cancer companies including AstraZeneca, Arvinas, Madison Vaccines, Phosplatin Therapeutics, Hinova Pharmaceuticals, Bristol Myers Squibb, Merck, MacroGenics, Daiichi Sankyo, Seagen, Taiho Pharmaceutical, Modra Pharmaceuticals, Xencor, Point Biopharma, Lantheus Holdings, Zenith Epigenetics, Essa Pharma, Telix Pharmaceuticals, Kintor Pharmaceutical, AB Science, Eli Lilly and Company, Exelixis among others.
Metastatic Castration-Sensitive Prostate Cancer Market [https://www.delveinsight.com/report-store/metastatic-castration-sensitive-prostate-cancer-mcspc-market?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]
Metastatic Castration-Sensitive Prostate Cancer Market Insights, Epidemiology, and Market Forecast - 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, market share of the individual therapies, and key mCSPC companies including Myovant Sciences, Pfizer, Bayer, Orion, Novartis, AstraZeneca, Pfizer, Janssen, Merck, Eli Lilly, among others.
Metastatic Castration-Sensitive Prostate Cancer Pipeline [https://www.delveinsight.com/report-store/metastatic-castration-sensitive-prostate-cancer-pipeline-insight?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]
Metastatic Castration-Sensitive Prostate Cancer Pipeline Insight - 2024 report provides comprehensive insights about the pipeline landscape, including clinical and non-clinical stage products, and the key mCSPC companies, including Myovant Sciences, Pfizer, Bayer, Orion, Novartis, AstraZeneca, Pfizer, Janssen, Merck, Eli Lilly, among others.
About DelveInsight
DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve.
Contact Us
Shruti Thakur
info@delveinsight.com [mailto:info@delveinsight.com]
+14699457679
www.delveinsight.com [https://www.delveinsight.com/]
Logo: https://mma.prnewswire.com/media/1082265/3528414/DelveInsight_Logo.jpg [https://mma.prnewswire.com/media/1082265/3528414/DelveInsight_Logo.jpg]
View original content:https://www.prnewswire.co.uk/news-releases/metastatic-castration-resistant-prostate-cancer-clinical-trial-pipeline-appears-robust-with-90-key-pharma-companies-actively-working-in-the-therapeutics-segment--delveinsight-302272435.html [https://www.prnewswire.co.uk/news-releases/metastatic-castration-resistant-prostate-cancer-clinical-trial-pipeline-appears-robust-with-90-key-pharma-companies-actively-working-in-the-therapeutics-segment--delveinsight-302272435.html]
Photo: https://mma.prnewswire.com/media/1082265/3528414/DelveInsight_Logo.jpg DelveInsight Business Research, LLP
