Multiple sclerosis (MS) is a chronic neurological disorder affecting the central nervous system (CNS), particularly the brain, spinal cord, and optic nerves. Continuous research has led to new drug developments, particularly disease-modifying therapies (DMTs) that slow MS progression. Monoclonal antibodies, oral therapies, and infusion treatments are among the most promising options and drives the multiple sclerosis market.
LAS VEGAS, Nov. 13, 2024 /PRNewswire/ -- DelveInsight's 'Multiple Sclerosis Pipeline Insight 2024 [https://www.delveinsight.com/report-store/multiple-sclerosis-pipeline-insight?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]' report provides comprehensive global coverage of pipeline multiple sclerosis therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the multiple sclerosis pipeline domain.
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Key Takeaways from the Multiple Sclerosis Pipeline Report
-- DelveInsight's multiple sclerosis pipeline report depicts a robust space
with 75+ active players working to develop 80+ pipeline therapies for
multiple sclerosis treatment.
-- Key multiple sclerosis companies such as Mapi Pharma, Novartis, Immunic,
Biocad, Apimeds, Genentech (Roche), AB Science, Celltrion, Clene
Nanomedicine, InnoCare Pharma, Oryzon Genomics, GeNeuro SA, AbbVie,
BrainStorm Cell Therapeutics, NeuroSense Therapeutics, Denali
Therapeutics Inc., Sanofi, MediciNova, Biogen, Tiziana Life Sciences,
Antisense Therapeutics, RemeGen, Atara Biotherapeutics, Contineum
Therapeutics, Eli Lilly and Company, Axsome Therapeutics, Accure
therapeutics, Stem Cell Medicine Ltd., Ever Supreme Bio-Technology Co.,
Ltd., ImCyse, Lucid Psycheceuticals, Immune Response BioPharma,
Guangzhou Lupeng Pharmaceutical, Kyowa Kirin, Nura Bio, Bristol-Myers
Squibb, ImStem Biotechnology, Hoffmann-La Roche, LAPIX Therapeutics,
Motric Bio, Immunophage Biotech, NervGen, FibroBiologics, Kyverna
Therapeutics, GlaxoSmithKline, PolTREG, Cyxone, Biohaven
Pharmaceuticals, HuniLife Biotechnology, GlobeStar Therapeutics,
Anokion, Medsenic, ZyVersa Therapeutics, Alumis Inc., Axoltis Pharma,
Barricade Therapeutics, BioNxt Solutions, Eikonoklastes Therapeutics, 4D
Pharma, Gossamer Bio, Pasithea Therapeutics, Synaptogenix, Monte Rosa
Therapeutics, Immix Biopharma, f5 Therapeutics, Autobahn Therapeutics,
Biosenic, Polpharma Biologics, Find Therapeutics, TeraImmun,
AptaTargets, Trethera, Aditxt, SetPoint Medical, Sarepta Therapeutics,
Nucleome Therapeutics, Vaccinex Inc., and others are evaluating new
multiple sclerosis drugs to improve the treatment landscape.
-- Promising multiple sclerosis pipeline therapies such as GA Depot,
Remibrutinib, Tolebrutinib, IMU 838, BCD-132, Apitox, Fenebrutinib, SAR
441344, CT-P53, CNM-Au8, Orelabrutinib, Vafidemstat, Temelimab,
Elezanumab, NurOwn (MSC-NTF cells), PrimeC, SAR4433820, Ibudilast,
BIIB091, Foralumab, ATL1102, RC18, ATA188, PIPE-307, Pirtobrutinib,
LY3541860, Solriamfetol, Act-01, SCM-010, UMSC01, IMCY-0141, Lucid-MS,
NeuroVax, LP-168, NB-4746, CC-97540, IMS-001, RO7121932, BMS-986196,
LPX-TI641, MTR-601, IPG-11406, IPG-1094, NVG-291, CYMS-101, KYV-101,
PIPE-791, GSK 3888130B, PTG-007, T 20K, BHV-8000, HuL001, Amethyst(TM),
ANK 700, Arscimed, A-005, NX210c, Research programme: CAR-TREG, TASIN-1,
Cladribine ODF, ET-101, MRx0002, GB7208, PAS-002, Bryostatin-1,
MRT-6160, NXC-201, Research Program: Cytokine reduction, ABX-002,
Arsenic trioxide, LL-341070, PB018, FTX 101, TI-235, TRE 515, NT-0007,
NT-0002, NVG300, and others are under different phases of multiple
sclerosis clinical trials.
-- In October 2024, Immunic, Inc. reported favorable results from the
non-binding interim futility analysis of its Phase 3 ENSURE trial, which
is evaluating its lead candidate, vidofludimus calcium (IMU-838), a
nuclear receptor-related 1 (Nurr1) activator, for the treatment of
relapsing multiple sclerosis (RMS).
-- In October 2024, Immunic, Inc. announced a positive outcome of the
non-binding, interim futility analysis of its Phase III ENSURE program,
investigating lead asset, nuclear receptor related 1 (Nurr1) activator,
vidofludimus calcium (IMU-838), for the treatment of relapsing multiple
sclerosis (RMS). Based on the outcome of the interim futility analysis,
an unblinded Independent Data Monitoring Committee (IDMC) has
recommended that the trials are not futile and should continue as
planned.
-- In September 2024, Roche, secured FDA approval for an injectable form of
its blockbuster multiple sclerosis treatment, Ocrevus, reducing patient
treatment time and potentially helping the company stay ahead of
increasing competition.
-- In September 2024, Sanofi announced the outcomes of Phase III clinical
trials of its investigational oral brain-penetrant BTK inhibitor,
tolebrutinib, aimed at treating multiple sclerosis (MS). These studies,
namely HERCULES, GEMINI 1, and GEMINI 2, have provided mixed results,
with the HERCULES trial meeting its primary endpoint while the GEMINI
trials did not. The HERCULES study focused on the efficacy and safety of
tolebrutinib in individuals with non-relapsing secondary progressive MS
(nrSPMS) compared to a placebo.
-- In August 2024, Abata Therapeutics announced that the U.S. Food and Drug
Administration (FDA) has granted Fast Track designation for ABA-101 for
the treatment of patients with progressive multiple sclerosis (MS). The
FDA recently cleared ABA-101's Investigational New Drug (IND)
application, and initiation of a first-in-human (FIH) Phase I study is
imminent.
-- In August 2024, TG Therapeutics announced that the FDA has cleared an
investigational new drug (IND) application submitted by TG Therapeutics
for azercabtagene zapreleucel (azer-cel), an investigational allogeneic
chimeric antigen receptor T-cell (CAR-T) therapy, for a phase 1 clinical
trial in patients with progressive multiple sclerosis (MS).
-- In January 2024, Kyverna Therapeutics, Inc. announced it received
fast-track designation by the U.S. Food and Drug Administration (FDA)
for its autologous, fully human CD19 chimeric antigen receptor (CAR)
T-cell product candidate, KYV-101, to be used for the treatment of
multiple sclerosis (MS).
Request a sample and discover the recent advances in multiple sclerosis treatment drugs @ Multiple Sclerosis Pipeline Report [https://www.delveinsight.com/sample-request/multiple-sclerosis-pipeline-insight?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]
The multiple sclerosis pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage multiple sclerosis drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the multiple sclerosis clinical trial landscape.
Multiple Sclerosis Overview
Multiple sclerosis is a chronic autoimmune disorder that affects the central nervous system, leading to the deterioration or permanent damage of myelin, the protective sheath surrounding nerve fibers. While the exact cause of multiple sclerosis remains unclear, it is believed to involve a combination of genetic predisposition, environmental factors, and possibly viral infections. Common symptoms of multiple sclerosis include fatigue, difficulty walking, numbness or tingling in the limbs, muscle weakness, and vision problems, which can vary significantly among individuals and may evolve over time.
Diagnosis typically involves a combination of neurological examinations, magnetic resonance imaging (MRI) to detect lesions in the brain and spinal cord, and sometimes lumbar puncture to analyze cerebrospinal fluid for inflammatory markers. While there is no cure for multiple sclerosis, treatment options aim to manage symptoms, reduce the frequency and severity of relapses, and slow disease progression. This may include disease-modifying therapies (DMTs), corticosteroids for acute exacerbations, and symptomatic treatments such as physical therapy, pain management, and lifestyle modifications. Early diagnosis and a tailored treatment plan are crucial for improving the quality of life for those living with multiple sclerosis.
Find out more about multiple sclerosis treatment drugs @ Drugs for Multiple Sclerosis Treatment [https://www.delveinsight.com/sample-request/multiple-sclerosis-pipeline-insight?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]
A snapshot of the Multiple Sclerosis Pipeline Drugs mentioned in the report:
Drugs Company Phase MoA RoA GA Depot Mapi Pharma Registered Immunomodulators; MHC class II gene modulators Intramuscular Remibrutinib Novartis Phase III Agammaglobulinemia tyrosine kinase inhibitors Oral Tolebrutinib Sanofi Phase III Agammaglobulinaemia tyrosine kinase inhibitors Oral IMU 838 Immunic Phase III Dihydroorotate dehydrogenase inhibitors; Nuclear receptor subfamily 4 group A member 2 agonists Oral BCD-132 Biocad Phase III CD20 antigen inhibitors Intravenous CNM-Au8 Clene Nanomedicine Phase II/ III Energy metabolism stimulants; Immunomodulators Oral NeuroVax Immune Response BioPharma Phase II/ III Immunostimulants Intramuscular Orelabrutinib InnoCare Pharma Phase II Agammaglobulinaemia tyrosine kinase inhibitors Oral Vafidemstat Oryzon Genomics Phase II Lysine-specific demethylase 1 inhibitors; Monoamine oxidase B inhibitors Oral Lucid-MS Lucid Psycheceuticals Phase I Protein-arginine deiminase inhibitors Oral LP-168 Guangzhou Lupeng Pharmaceutical Phase I Agammaglobulinaemia tyrosine kinase inhibitors Oral
Learn more about the emerging multiple sclerosis pipeline therapies @ Multiple Sclerosis Clinical Trials [https://www.delveinsight.com/sample-request/multiple-sclerosis-pipeline-insight?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]
Multiple Sclerosis Therapeutics Assessment
The multiple sclerosis pipeline report proffers an integral view of the multiple sclerosis emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration.
Scope of the Multiple Sclerosis Pipeline Report
-- Coverage: Global
-- Therapeutic Assessment By Product Type: Mono, Combination,
Mono/Combination
-- Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical,
Phase I, Phase II, Phase III
-- Therapeutics Assessment By Route of Administration: Oral, Intravenous,
Subcutaneous, Parenteral, Topical
-- Therapeutics Assessment By Molecule Type: Recombinant fusion proteins,
Small molecule, Monoclonal antibody, Peptide, Polymer, Gene therapy
-- Therapeutics Assessment By Mechanism of Action: Immunomodulators, MHC
class II gene modulators, Agammaglobulinaemia tyrosine kinase
inhibitors, Dihydroorotate dehydrogenase inhibitors, Nuclear receptor
subfamily 4 group A member 2 agonists, CD20 antigen inhibitors, Energy
metabolism stimulants; Immunomodulators, Lysine-specific demethylase 1
inhibitors, Monoamine oxidase B inhibitors, Protein-arginine deiminase
inhibitors, Immunostimulants
-- Key Multiple Sclerosis Companies: Mapi Pharma, Novartis, Immunic,
Biocad, Apimeds, Genentech (Roche), AB Science, Celltrion, Clene
Nanomedicine, InnoCare Pharma, Oryzon Genomics, GeNeuro SA, AbbVie,
BrainStorm Cell Therapeutics, NeuroSense Therapeutics, Denali
Therapeutics Inc., Sanofi, MediciNova, Biogen, Tiziana Life Sciences,
Antisense Therapeutics, RemeGen, Atara Biotherapeutics, Contineum
Therapeutics, Eli Lilly and Company, Axsome Therapeutics, Accure
therapeutics, Stem Cell Medicine Ltd., Ever Supreme Bio-Technology Co.,
Ltd., ImCyse, Lucid Psycheceuticals, Immune Response BioPharma,
Guangzhou Lupeng Pharmaceutical, Kyowa Kirin, Nura Bio, Bristol-Myers
Squibb, ImStem Biotechnology, Hoffmann-La Roche, LAPIX Therapeutics,
Motric Bio, Immunophage Biotech, NervGen, FibroBiologics, Kyverna
Therapeutics, GlaxoSmithKline, PolTREG, Cyxone, Biohaven
Pharmaceuticals, HuniLife Biotechnology, GlobeStar Therapeutics,
Anokion, Medsenic, ZyVersa Therapeutics, Alumis Inc., Axoltis Pharma,
Barricade Therapeutics, BioNxt Solutions, Eikonoklastes Therapeutics, 4D
Pharma, Gossamer Bio, Pasithea Therapeutics, Synaptogenix, Monte Rosa
Therapeutics, Immix Biopharma, f5 Therapeutics, Autobahn Therapeutics,
Biosenic, Polpharma Biologics, Find Therapeutics, TeraImmun,
AptaTargets, Trethera, Aditxt, SetPoint Medical, Sarepta Therapeutics,
Nucleome Therapeutics, Vaccinex Inc., and others are evaluating new
multiple sclerosis drugs to improve the treatment landscape.
-- Key Multiple Sclerosis Pipeline Therapies:GA Depot, Remibrutinib,
Tolebrutinib, IMU 838, BCD-132, Apitox, Fenebrutinib, SAR 441344,
CT-P53, CNM-Au8, Orelabrutinib, Vafidemstat, Temelimab, Elezanumab,
NurOwn (MSC-NTF cells), PrimeC, SAR4433820, Ibudilast, BIIB091,
Foralumab, ATL1102, RC18, ATA188, PIPE-307, Pirtobrutinib, LY3541860,
Solriamfetol, Act-01, SCM-010, UMSC01, IMCY-0141, Lucid-MS, NeuroVax,
LP-168, NB-4746, CC-97540, IMS-001, RO7121932, BMS-986196, LPX-TI641,
MTR-601, IPG-11406, IPG-1094, NVG-291, CYMS-101, KYV-101, PIPE-791, GSK
3888130B, PTG-007, T 20K, BHV-8000, HuL001, Amethyst(TM), ANK 700,
Arscimed, A-005, NX210c, Research programme: CAR-TREG, TASIN-1,
Cladribine ODF, ET-101, MRx0002, GB7208, PAS-002, Bryostatin-1,
MRT-6160, NXC-201, Research Program: Cytokine reduction, ABX-002,
Arsenic trioxide, LL-341070, PB018, FTX 101, TI-235, TRE 515, NT-0007,
NT-0002, NVG300, and others are under different phases of multiple
sclerosis clinical trials.
Dive deep into rich insights for new drugs for multiple sclerosis treatment, visit @ Multiple Sclerosis Drugs [https://www.delveinsight.com/sample-request/multiple-sclerosis-pipeline-insight?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]
Table of Contents
1. Multiple Sclerosis Pipeline Report Introduction 2. Multiple Sclerosis Pipeline Report Executive Summary 3. Multiple Sclerosis Pipeline: Overview 4. Analytical Perspective In-depth Commercial Assessment 5. Multiple Sclerosis Clinical Trial Therapeutics 6. Multiple Sclerosis Pipeline: Late-Stage Products (Pre-registration) 7. Multiple Sclerosis Pipeline: Late-Stage Products (Phase III) 8. Multiple Sclerosis Pipeline: Mid-Stage Products (Phase II) 9. Multiple Sclerosis Pipeline: Early-Stage Products (Phase I) 10. Multiple Sclerosis Pipeline Therapeutics Assessment 11. Inactive Products in the Multiple Sclerosis Pipeline 12. Company-University Collaborations (Licensing/ Partnering) Analysis 13. Key Companies 14. Key Products in the Multiple Sclerosis Pipeline 15. Unmet Needs 16. Market Drivers and Barriers 17. Future Perspectives and Conclusion 18. Analyst Views 19. Appendix
For further information on the multiple sclerosis pipeline therapeutics, reach out @ Multiple Sclerosis Treatment Drugs [https://www.delveinsight.com/sample-request/multiple-sclerosis-pipeline-insight?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]
Related Reports
Multiple Sclerosis Market [https://www.delveinsight.com/report-store/multiple-sclerosis-market?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]
Multiple Sclerosis Market Insights, Epidemiology, and Market Forecast - 2034 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, market share of the individual therapies, and key multiple sclerosis companies including Immune Response BioPharma, Inc., Clene Nanomedicine, Genzyme, ImStem Biotechnology, Rho, Inc., Bristol-Myers Squibb, TG Therapeutics, Inc., Hoffmann-La Roche, Atara Biotherapeutics, Immunic AG, Celgene, Anokion SA, Sanofi, Actelion, Biogen, Supernus Pharmaceuticals, Inc., GeNeuro SA, HuniLife Biotechnology, Inc., Emerald Health Pharmaceuticals, RemeGen Co., Ltd., Antisense Therapeutics, Biocad, AB Science, Genentech, Novartis, Pipeline Therapeutics, ASLAN Pharmaceuticals, GlaxoSmithKline, Lucid Psycheceuticals, Voronoi, Hanmi Pharmaceutical, Mapi Pharma, f5 Therapeutics, Autobahn Therapeutics, AstraZeneca, ZyVersa Therapeutics, RedHill Biopharma, Gossamer Bio, Sarepta Therapeutics, BrainStorm Cell Limited, CytoDyn, Pear Therapeutics, Solstice Neurosciences, ProJenX, among others.
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Multiple Sclerosis Epidemiology Forecast - 2032 report delivers an in-depth understanding of the disease, historical and forecasted multiple sclerosis epidemiology in the 7MM, i.e., the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan.
Relapsing Multiple Sclerosis Pipeline [https://www.delveinsight.com/report-store/relapsing-multiple-sclerosis-rms-pipeline-insight?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]
Relapsing Multiple Sclerosis Pipeline Insight - 2024 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key relapsing multiple sclerosis companies, including ASLAN Pharmaceuticals, GlaxoSmithKline, Lucid Psycheceuticals, Voronoi, Hanmi Pharmaceutical, among others.
Relapsing-Remitting Multiple Sclerosis Pipeline [https://www.delveinsight.com/report-store/relapsing-remitting-multiple-sclerosis-pipeline-insight?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr]
Relapsing-Remitting Multiple Sclerosis Pipeline Insight - 2024 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key RRMS companies, including TG Therapeutics, Novartis, Sanofi, Cinnagen, Polpharma Biologics, Immunic, Mapi Pharma, Biocad, Apimeds, Genentech (Roche), Merck, Immune Response BioPharma, Clene Nanomedicine, InnoCare Pharma, Oryzon Genomics, GeNeuro SA, AbbVie, Emerald Health Pharmaceuticals, GlaxoSmithKline, RedHill Biopharma, among others.
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